CBD For ALS

Conventional therapeutic aids for ALS work by suppressing oxidative stress and inflammation while providing neuro-protectivity. CBD has all these properties and it can be used as a monotherapy or single administration drug for improving the symptoms of ALS. Several studies have shown that CBD has antioxidant, anti-inflammatory and neuroprotective benefits. That means it can be used to prolong the survival of neuronal cells and to prevent worsening of the condition, if not its onset. In addition, CBD may help with other ALS symptoms through the promotion of bronchodilation and muscle relaxation as well as improving appetite and sleep. The cannabinoid activates CB1 receptors thereby exerting anti-glutamatergic action by inhibiting the release of glutamate from the presynaptic nerve terminals. This reduces postsynaptic calcium influx as well as glutamate excitotoxicity within the motor neurons. Similarly, CB2 receptors’ activation provides anti-inflammatory benefits because it influences inflammatory mechanisms that include microglial activation inhibition and subsequent reduction in the microglia-derived neurotoxic mediators. A receptor-independent mechanism exerts the antioxidant benefits of CBD. Animal studies have shown that CBD administration delays the onset of the symptoms of ALS.

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